Nitric oxide and cellular immunity in experimental cutaneous leishmaniasis
| Autor: | Nilka L. Díaz, M. Fernández, I. B. Monsalve, E. Figueira, Félix J. Tapia, Richard Ramírez |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Cellular immunity
biology medicine.medical_treatment Interleukin Dermatology biology.organism_classification Molecular biology Leishmania mexicana Nitric oxide Nitric oxide synthase Lesion chemistry.chemical_compound Cytokine chemistry Interferon Immunology medicine biology.protein medicine.symptom medicine.drug |
| Zdroj: | Clinical and Experimental Dermatology. 28:288-293 |
| ISSN: | 0307-6938 |
| DOI: | 10.1046/j.1365-2230.2003.01206.x |
| Popis: | We examined the local and systemic production of nitric oxide (NO) and the pattern of cytokine during the course of Leishmania mexicana infection in susceptible BALB/c and resistant C57BL/6 mice. NO derivatives were measured in serum, and the expression of inducible nitric oxide synthase (iNOS), interferon (IFN-gamma), interleukin (IL-4) and epidermal Langerhans cells (LC) was measured in the lesions by immunohistology. Circulating NO concentrations, iNOS+ cell density, IFN-gamma+ Th1 cells and CD205+ Langerhans cells were higher in early lesions of resistant C57BL/6 mice. In contrast, susceptible BALB/c mice developed chronic and progressive lesions with a predominance of IL-4+ Th2 cells. In both susceptible and resistant mice, lesion size and lymph node volume followed a similar course. The early local and systemic production of NO in resistant mice may be related with the premature production of IFN-gamma observed, contributing to the resolution of the lesion. |
| Databáze: | OpenAIRE |
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