Reducing-Agent-Free Convergent Synthesis of Hydroxyimino-Decorated Tetracyclic Fused Cinnolines via RhIII-Catalyzed Annulation Using Nitroolefins

Autor:	Rajeev Sakhuja, Chikkagundagal K. Mahesha, Sanjay K. Mandal, Pidiyara Karishma
Rok vydání:	2021
Předmět:	Olefin fiber Annulation 010405 organic chemistry Reducing agent Organic Chemistry Convergent synthesis chemistry.chemical_element 010402 general chemistry Oxime 01 natural sciences Combinatorial chemistry 0104 chemical sciences Rhodium Catalysis chemistry.chemical_compound chemistry
Zdroj:	The Journal of Organic Chemistry. 86:2734-2747
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.0c02729
Popis:	A mild Rh-catalyzed method was developed for the synthesis of hydroxyimino functionalized indazolo[1,2-a]cinnolines and phthalazino[2,3-a]cinnolines by reductive [4 + 2] annulation between 1-arylindazolones and 2-aryl-2,3-dihydrophthalazine-1,4-diones with varied nitroolefins. The targeted oxime decorated tetracyclic fused cinnolines were synthesized via sequential C-H activation/olefin insertion/reduction under reducing-agent-free conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2213789e821eb45ddb2a6c3fd088c82f https://doi.org/10.1021/acs.joc.0c02729 Zobrazit plný text záznamu