Abstract 4320: Circulating vitamin D2 and D3 levels and single nucleotide polymorphism associations with lung cancer status: A case-control study
| Autor: | Ezra Margono, Elise D. Bowman, Bríd M. Ryan, Frank J. Gonzalez, Majda Haznadar, Kristopher W. Krausz, Curtis C. Harris |
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| Rok vydání: | 2016 |
| Předmět: |
Calcium metabolism
Vitamin Cancer Research medicine.medical_specialty business.industry Case-control study Cancer Physiology Single-nucleotide polymorphism medicine.disease Micronutrient chemistry.chemical_compound Endocrinology Oncology chemistry Internal medicine Vitamin D and neurology Medicine business Lung cancer |
| Zdroj: | Cancer Research. 76:4320-4320 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.am2016-4320 |
| Popis: | Vitamin D is an essential micronutrient, required for normal physiological function and classically recognized for its role regulating calcium metabolism. Recent work is beginning to demonstrate a role of vitamin D in chronic illnesses, such as cancer, but questions addressing how depletion of this nutrient affects cancer risk remain largely unanswered. In 2011, the Institute of Medicine report highlighted the need for more research to explore the role of vitamin D in non-skeletal health outcomes. Previously, vitamin D has largely been measured using radio- and chemiluminescence immunoassays, unable to distinguish between D2 (from plant dietary sources and supplements) and D3 forms. We measured circulating serum levels of both, inactive (25(OH)D), and active (1,25(OH)2D) forms of D2 and D3 using sensitive liquid chromatography coupled to mass spectrometry in 406 lung cancer cases and 437 controls. We observed that levels of inactive D3 are associated with decreased lung cancer risk across quartiles, after adjustment for age, gender, race, smoking status, pack years, interview year and blood collection month (ORadjusted = 0.5 (95% CI = 0.2, 0.9), P < 0.02; Ptrend Citation Format: Majda Haznadar, Kristopher W. Krausz, Ezra Margono, Elise D. Bowman, Brid M. Ryan, Frank J. Gonzalez, Curtis C. Harris. Circulating vitamin D2 and D3 levels and single nucleotide polymorphism associations with lung cancer status: A case-control study. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4320. |
| Databáze: | OpenAIRE |
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