Neuroendocrine differentiation in stage D2 prostate cancers
| Autor: | Koji Kawamura, Kunio Yamaguchi, Naoto Kamiya, Hiroyoshi Suzuki, Yukio Naya, Yukio Kakuta, Naobumi Tochigi, Hiroshi Ishikura, Tomohiko Ichikawa, Takashi Imamoto |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Oncology
endocrine system Pathology medicine.medical_specialty biology business.industry Urology Chromogranin A Neuroendocrine tumors medicine.disease Neuroendocrine differentiation Prostate-specific antigen Prostate cancer medicine.anatomical_structure nervous system Prostate Internal medicine biology.protein Immunohistochemistry Medicine business Tumor marker |
| Zdroj: | International Journal of Urology. 15:423-428 |
| ISSN: | 0919-8172 |
| DOI: | 10.1111/j.1442-2042.2008.02015.x |
| Popis: | Objectives: Chromogranin A (CgA) and neuro-specific enolase (NSE) are gaining acceptance as markers of several types of neuroendocrine tumors and the concentration of CgA and NSE have been reported to be elevated in relation to neuroendocrine differentiation of prostate cancer. The aim of the present study was to examine the correlation between the immunohistochemical (IHC) findings and serum value for CgA and NSE in untreated stage D2 prostate cancer patients. Methods: Immunohistochemistry was carried out using antibodies against CgA and NSE in 58 patients and, pretreatment serum CgA and NSE levels were measured by monoclonal immunoradiometric assay in 18 patients with stage D2 prostate cancer treated by androgen ablation. We examined the relationship of the pretreatment serum level to IHC findings for CgA and NSE in prostate cancer patients to clinicopathological parameters, and prognosis. Also, we evaluated the correlation of IHC findings to serum levels for CgA and NSE. Results: There was a statistically significant correlation between CgA positivity and serum CgA level (P = 0.0421). However, there was no statistically significant correlation between NSE positivity and serum NSE level (P > 0.05). We divided stage D2 patients into three groups according to IHC positivity of CgA and NSE. The cause-specific survival was significantly poorer in patients with strongly positive (++) patients for independent CgA and combined CgA with NSE (P = 0.0379). Multivariate analysis of cause-specific survivals in patients with stage D2 prostate cancer demonstrated that strong IHC stain was considered as independent variable associated with greater risk of death (P = 0.0142). Conclusion: Neuroendocrine differentiation in stage D2 prostate cancer has attracted considerable attention as a potentially findings prognosis. Thus, CgA had a stronger relationship between serum levels and IHC positivity in contrast to NSE, suggesting clinical usefulness as a tumor marker in predicting the extent of neuroendocrine differentiation in prostate cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|