| Popis: |
In an attempt to synthesize antibacterial agents effective against gram-positive and gram-negative bacteria, the efficient synthesis of novel bis-azetidinones (3a–j) has been established. Thus, cycloaddition reaction of substituted bis-imines with chloroacetylchloride under microwave irradiation in the presence of zeolite yielded bis-azetidinones (3a–j). Structures of the synthesized compounds have been elucidated on the basis of their elemental analysis and spectral data (IR, 1H-NMR, 13C-NMR, and mass spectra). The synthesized bis-azetidinones were screened for their antibacterial activity against five microorganisms: Bacillus subtilis, Proteus vulgaris, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. They were found to exhibit good to moderate antibacterial activity. |
