| Autor: |
Basant K. Puri, Gary S. Lee, Armin Schwarzbach |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Recent Advances in Inflammation & Allergy Drug Discovery. 16:16-18 |
| ISSN: |
2772-2708 |
| Popis: |
Background: Preliminary evidence has pointed an association of the gene HLA-DRB1 with fibromyalgia. HLA-DRB1 alleles carrying the shared or susceptibility epitope encoding the five-amino acid motif QKRAA, QRRAA or RRRAA in positions 70 to 74 of the major histocom-patibility complex class II DRβ chain are associated with several autoimmune diseases. Objective: The objective of this study was to test the hypothesis that susceptibility epitope-encoding HLA-DRB1 alleles are associated with fibromyalgia. Methods: Using a case-control design, the prevalence of susceptibility epitope-encoding HLA-DRB1 alleles in 27 white Caucasian patients fulfilling the revised diagnostic criteria for fibromyal-gia of the American College of Rheumatology was compared with that in 27 white Caucasian age- and sex-matched healthy controls. Results: 13 (48%) of the fibromyalgia patients had susceptibility epitope-coding HLA-DRB1 alleles compared with 15 (56%) of the controls (P = 0.785). The DRB1*01 allele encoding the protective epitope 70-DERAA-74 motif was found in one of the control subjects; none of the fibromyalgia patients had such a protective epitope. Conclusion: While the present study does not provide evidence supporting the potential role of HLA-DRB1 in the etiology of fibromyalgia, it does not exclude the possibility that there is a poly-genic component to a putative genetic causative role. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
