Helicobacter pylorieradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis
Autor: | Masaharu Sumii, S. Tanaka, Kazuaki Chayama, Mitsuhiro Mihara, Masaharu Yoshihara, Ken Haruma, Masanori Ito, Tomoari Kamada, Yasuhiko Kitadai, Sun Jin Kim |
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Rok vydání: | 2002 |
Předmět: |
medicine.medical_specialty
Hepatology biology Atrophic gastritis business.industry Spirillaceae Gastroenterology Intestinal metaplasia Helicobacter pylori medicine.disease biology.organism_classification Atrophy Internal medicine medicine Pharmacology (medical) Gastritis medicine.symptom business Antrum Gastrin |
Zdroj: | Alimentary Pharmacology & Therapeutics. 16:1449-1456 |
ISSN: | 0269-2813 |
Popis: | SUMMARY Aim : To investigate the effect of the eradication of Helicobacter pylori on histological gastritis. Methods : Twenty-six patients with moderate to severe atrophy received successful eradication therapy of H.pylori. Four patients dropped out and 22 were followed up prospectively for 5 years. The grades of gastritis were estimated from gastric biopsy specimens. The grade of intestinal metaplasia was also evaluated by dye-endoscopy using methylene blue (methylthioninium chloride). The serum levels of pepsinogen, gastrin and anti-parietal cell antibody were also determined. Results : The grades of atrophy decreased in patients with successful eradication therapy in the gastric corpus (before vs. 5 years after eradication, 2.09 ± 0.15 vs. 0.91 ± 0.17; P |
Databáze: | OpenAIRE |
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