Increase of the anti-HIV activity of D4T in human T-cell culture by the use of the sate pronucleotide approach
| Autor: | Gilles Gosselin, Christian Périgaud, André Kirn, J.‐L. Imbach, Anne-Marie Aubertin, Jean-Luc Girardet |
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| Rok vydání: | 1995 |
| Předmět: |
Anti hiv activity
T cell Organic Chemistry Clinical Biochemistry Pharmaceutical Science Nanotechnology Biochemistry Virology chemistry.chemical_compound medicine.anatomical_structure chemistry Cell culture Drug Discovery medicine Molecular Medicine Molecular Biology Nucleoside Derivative (chemistry) |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 5:2981-2984 |
| ISSN: | 0960-894X |
| Popis: | The bis( S -acetyl-2-thioethyl) phosphotriester derivative of 2′,3′-didehydro-2′,3′-dideoxythymidine has been synthesized and evaluated for its inhibitory effects on the replication of HIV-1 in several cell culture systems. This pronucleotide showed potent anti-HIV activity and proved to be significantly superior to the parent nucleoside with regard to the antiviral efficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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