7H-BENZO[C]FLUORENE: A POTENT SYSTEMIC LUNG CARCINOGEN

Autor: Eric H. Weyand, Ji-Quan Wang, Ronald G. Harvey, Lawrence S.B. Goldstein, Bhama Parimoo, Kenneth R. Reuhl
Rok vydání: 2004
Předmět:
Zdroj: Polycyclic Aromatic Compounds. 24:1-20
ISSN: 1563-5333
1040-6638
DOI: 10.1080/10406630490426942
Popis: 7H-Benzo[c]fluorene (B[c]F) is a major lung deoxyribonucleic acid (DNA) adductor in mice treated with coal tar suggesting that B[c]F may be capable of inducing lung tumors. This study evaluated the tumorigenic potential of B[c]F in comparison to benzo[a]pyrene (B[a]P) using the A/J mouse model. Female A/J mice 7 weeks of age were administered B[c]F or B[a]P (100 mg/kg) by i.p. injection. These mice were fed Purina Rodent 2001 diet for the remainder of the study. Groups of mice were also fed diets containing B[c]F (397 or 27 μmol/kg diet) or B[a]P (397 μmol/kg diet). In addition, a mixture of 20 synthetic polycyclic aromatic hydrocarbons (PAHs) known to be present in coal tar was also fed to mice in the presence or absence of B[c]F. A basal gel diet system was used to administer hydrocarbons within the diet. Mice were maintained on control or adulterated diets for 260 days. B[c]F administered i.p. induced multiple lung tumors in 92% of the treated mice, with an average of 4.0 tumors per mouse. Similarly, B...
Databáze: OpenAIRE
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