Synthesis of new polyfunctionally substituted pyridazines, phthalazines, cinnolines and thieno[3,4-c]pyridazines
Autor: | Hesham Roshdy, Salah M. El-Kousy, Mohamed Hilmy Elnagdi, Abdel Monem A Eltorgoman, Ibraheim Elsakka |
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Rok vydání: | 1990 |
Předmět: | |
Zdroj: | Collection of Czechoslovak Chemical Communications. 55:2977-2986 |
ISSN: | 1212-6950 0010-0765 |
DOI: | 10.1135/cccc19902977 |
Popis: | The reaction of ethyl 2-arylhydrazono-3-oxobutyrates (Ia, Ib) with active methylene ketones afforded pyridazin-5-carbonitrile derivatives. The methyl function in the ethyl pyridazin-3-carboxylate derivatives IIa, IIb reacted with arylidenemalononitrile to yield the phthalazine derivatives Va-Vf and with elemental sulfur to yield the thienopyridazines XIXa, XIXb. The cinnolines are producted from reaction of IIa, IIb with diethyl acetonedicarboxylate. |
Databáze: | OpenAIRE |
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