Synthesis of new polyfunctionally substituted pyridazines, phthalazines, cinnolines and thieno[3,4-c]pyridazines

Autor: Hesham Roshdy, Salah M. El-Kousy, Mohamed Hilmy Elnagdi, Abdel Monem A Eltorgoman, Ibraheim Elsakka
Rok vydání: 1990
Předmět:
Zdroj: Collection of Czechoslovak Chemical Communications. 55:2977-2986
ISSN: 1212-6950
0010-0765
DOI: 10.1135/cccc19902977
Popis: The reaction of ethyl 2-arylhydrazono-3-oxobutyrates (Ia, Ib) with active methylene ketones afforded pyridazin-5-carbonitrile derivatives. The methyl function in the ethyl pyridazin-3-carboxylate derivatives IIa, IIb reacted with arylidenemalononitrile to yield the phthalazine derivatives Va-Vf and with elemental sulfur to yield the thienopyridazines XIXa, XIXb. The cinnolines are producted from reaction of IIa, IIb with diethyl acetonedicarboxylate.
Databáze: OpenAIRE