Disposition of Mulberry Pollen in the Human Respiratory System: A Mathematical Model
| Autor: | T. B. Martonen, Mary Kay O'Rourke |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Inhalation exposure
education.field_of_study Veterinary medicine Lung Inhalation Population Aeroallergen Plant Science Anatomy Biology medicine.disease_cause medicine.anatomical_structure medicine Breathing Respiratory system education Ecology Evolution Behavior and Systematics Respiratory minute volume |
| Zdroj: | Grana. 32:290-301 |
| ISSN: | 1651-2049 0017-3134 |
| DOI: | 10.1080/00173139309429992 |
| Popis: | Inhaled particle deposition sites must be identified to effectively treat human airway diseases. We have determined distribution patterns of a selected aeroallergen, mulberry pollen, among human extrathoracic (ET: i.e., oronasopharyngeal) regions and the lung. A predictive model validated by inhalation exposure data from human subjects was utilized. Deposition locations were primarily functions of (1) mulberry particle parameters (geometric size, 11–18 μm; shape, spherical; and density, 1.14 g cm−3), and (2) mode of breathing. In the general population, two styles of inhalation are prevalent, normal augmentors (NAs) and mouth breathers (MBs). Their clinical definitions are based on intra-ET airflow divisions. For a NA-mode breathing sedentary (minute ventilation = VE = 10 L min−1) adult, 93% of inhaled mulberry pollen was removed by the ET compartment and 7% collected within the lung. For a MB, the respective deposition efficiencies were 75% and 25%. To apply the model, we used a daily springtime... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|