Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alfa therapy in chronic hepatitis C

Autor: Isabelle Descombes, Veronica Milotova, Nathalie Boyer, Corinne Castelnau, Patrick Marcellin, Jean Pierre Benhamou, Claude Degott, Véronique Le Breton, Marc Poliquin, Michèle Pouteau, Serge Erlinger, Michèle Martinot-Peignoux
Rok vydání: 1995
Předmět:
Zdroj: Hepatology. 22:1050-1056
ISSN: 1527-3350
0270-9139
DOI: 10.1002/hep.1840220406
Popis: The aim of the study was to determine the respective influence of pretreatment serum hepatitis C virus (HCV) RNA levels and HCV genotype on the response to interferon (IFN) alfa in patients with chronic hepatitis C. We retrospectively studied 141 patients with chronic hepatitis C included in two consecutive controlled trials of IFN alfa. A sustained response was observed in 28, a response followed by relapse in 43, and no response in 70 patients. Pretreatment serum HCV RNA quantitation with the branched DNA (bDNA) assay and HCV genotyping with reverse hybridization assay (LiPA) were performed in all patients. Seventy-four percent of the patients had detectable serum HCV RNA (43%, 77% and 84%) in the three groups of patients with sustained response, relapse, and no response, respectively ( P = .005). Mean serum HCV RNA level were 1.4 ± 6 x 10 6 , 4.8 ± 6 x 10 6 , and 3.9 ± 5 x 10 6 genomes/mL in patients with sustained response, response and relapse, and no response, respectively ( P
Databáze: OpenAIRE
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