Visible-light promoted one-pot synthesis of pyrazoles from alkynes and hydrazines
| Autor: | Chunyin Zhu, Te Zhang, Xinchi Gong, Yunge Meng, Min Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Annulation
010405 organic chemistry Organic Chemistry One-pot synthesis 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Tautomer 0104 chemical sciences chemistry.chemical_compound chemistry Phenylacetylene Intramolecular force Drug Discovery Functional group Glaser coupling Visible spectrum |
| Zdroj: | Tetrahedron Letters. 60:171-174 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2018.12.009 |
| Popis: | A visible-light promoted cascade of Glaser coupling/annulation has been developed for one-pot synthesis of polysubstituted pyrazoles from alkynes and hydrazines. The method features mild reaction conditions, readily availible starting materials and green oxidant (O2). It works for a wide range of substituted phenyl acetylene and hyrazines with good functional group tolerance and efficiency. Mechanistic pathways including photochemical irridiation, intramolecular hydrogen-atom-abstraction (HAT) and enamine-to-imine tautomerization was proposed for the transformation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect