The Effects of Aflatoxin B1 on Rat Fetal Lung Lipids
| Autor: | Salil K. Das, Marcel U.K. Mgbodile, Henry L. Patthey, Rajagopalan C. Nair |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Pregnancy Aflatoxin Lung Chemistry Lumen (anatomy) Gestational age respiratory system Lamellar granule medicine.disease Endocrinology medicine.anatomical_structure Biochemistry Pulmonary surfactant Internal medicine Pediatrics Perinatology and Child Health Toxicity medicine Developmental Biology |
| Zdroj: | Neonatology. 33:283-288 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000241085 |
| Popis: | The administration of aflatoxin B1 to rats on days 17 and 19 of pregnancy caused increased synthesis of the total lipids and the fatty acids, and decreased synthesis of the phosphatidyl choline in 21-day-old fetal lung. Aflatoxin B1 caused toxicity in the fetal lung as evidenced by the excessive accumulation of the lamellar bodies and the osmiophilic spheroids in the type II cells and the alveolar lumen, respectively. The rearrangement of the lamellar form to the continuous sheet-like tubular myelin form was reduced in the alveolar lumen of the treated lung. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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