Effects of calcium and potassium channel blockers on changes in transepithelial potential and spike responses in Lorenzi ampullary electroreceptors in Raja clavata

Autor:	V. I. Govardovskii, G. R. Broun, V. L. Cherepnov
Rok vydání:	1986
Předmět:	medicine.medical_specialty Physiology General Neuroscience Voltage clamp Potassium channel blocker Stimulation Biology Potassium channel Endocrinology Internal medicine medicine Excitatory postsynaptic potential Biophysics Verapamil Channel blocker Transepithelial potential difference medicine.drug
Zdroj:	Neurophysiology. 17:472-478
ISSN:	1573-9007 0090-2977
DOI:	10.1007/bf01052184
Popis:	The effects of TEA, 4-AP, Co++, Cd++, Cs+, EDTA, and verapamil on the sensory epithelium of ampullae of Lorenzini were studied inRaja clavata (Black Sea skate). During voltage clamping, transepithelial application of TEA to the basal surface caused oscillations in transepithelial potentials in response to presentation of an excitatory stimulus, which had been suppressed by Co++, Cd++, and EDTA. Application of Cs+ was followed by complete or partial suppression of spike response adaptation. When applied to the apical epithelial surface, TEA produced an increase in spike response to stimulation and highly accelerated adaption. No substantial changes took place after apical application of Co++, Cd++, and verapamil. The mechanisms of these phenomena are discussed.
Databáze:	OpenAIRE
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