High-affinity FKBP-12 ligands derived from (R)-(−)-carvone. Synthesis and evaluation of FK506 pyranose ring replacements

Autor:	J. V. French, Richard E. Showalter, Hans E. Parge, Vincent J. Kalish, Daniel R. Knighton, John H. Tatlock, Christina T. Lewis, J. Ernest Villafranca
Rok vydání:	1995
Předmět:	Carvone Rotamase activity Stereochemistry Effector Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Small molecule chemistry.chemical_compound FKBP Pyranose chemistry Drug Discovery Domain (ring theory) Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:2489-2494
ISSN:	0960-894X
DOI:	10.1016/0960-894x(95)00429-w
Popis:	The preparation and evaluation of potent small molecule inhibitors of FKBP-12 rotamase activity is described. These ligands contain many of the structural features of the FK506 pyranose ring region, yet are synthetically more accessible. The versatility of these FKBP-12 ligands is demonstrated with respect to effector domain exploration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::21ce686745ca70ec16a529ff6519260e https://doi.org/10.1016/0960-894x(95)00429-w Zobrazit plný text záznamu Full Text from ScienceDirect