Epinephrine-induced effects on cerebral microcirculation and oxygenation dynamics using multimodal monitoring and functional photoacoustic microscopy
| Autor: | Dong Zhang, Wei Wang, Xiaoyi Zhu, Ran Li, Wei Liu, Maomao Chen, Tri Vu, Laiming Jiang, Qifa Zhou, Cody L Evans, Dennis A Turner, Huaxin Sheng, Jerrold H Levy, Jianwen Luo, Wei Yang, Junjie Yao, Ulrike Hoffmann |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Anesthesiology. |
| ISSN: | 1528-1175 0003-3022 |
| DOI: | 10.1097/aln.0000000000004592 |
| Popis: | Background The administration of epinephrine after severe refractory hypotension, shock or cardiac arrest restores systemic blood flow and major vessel perfusion but may worsen cerebral microvascular perfusion and oxygen delivery through vasoconstriction. We hypothesized that epinephrine induces significant microvascular constriction in the brain, with increased severity after repetitive dosing and in the aged brain, eventually leading to tissue hypoxia. Methods We investigated the effects of intravenous epinephrine administration in healthy young and aged C57Bl/6 mice on cerebral microvascular blood flow and oxygen delivery using multimodal in vivo imaging, including functional photoacoustic microscopy, brain tissue oxygen sensing, and follow up histologic assessment. Results We report 3 main findings. First, after epinephrine administration, microvessels exhibited severe immediate vasoconstriction (57 ± 6% of baseline at 6 minutes, p Conclusions Intravenous application of epinephrine induced marked cerebral microvascular constriction, intravascular hemoglobin de-saturation, and paradoxically, an increase in brain tissue oxygen levels, likely due to reduced transit time heterogeneity. |
| Databáze: | OpenAIRE |
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