| Popis: |
Background The relationship between gut microbiota and obesity has recently been an important subject for research as the gut microbiota is thought to affect body homeostasis including body weight and composition, making the intervention with pro and prebiotics an intelligent possible way for obesity management. Aim To evaluate the effect of hypo caloric high fiber regimen, physical exercise and probiotic supplementation on the improvement of health, body composition and physique among obese Egyptian women. Methods The enrolled 58 women, in this longitudinal follow up intervention study; followed a weight loss eating regimen (prebiotic), included low-carbohydrate high-fiber high-protein dietary pattern with decreased energy intake. They additionally received daily probiotic supplement in form of yogurt, and were instructed to exercise regularly for 3 months. Anthropometric measurements, body composition, laboratory investigations and microbiota analysis were obtained before and after the 3 months weight loss program. Results Statistically highly significant differences in the anthropometry, body composition parameters: and obesity-related biomarkers (Leptin, ALT and AST) between the pre and post follow up measurements at the end of the study as they were all decreased. The prebiotic and probiotic supplementation induced statistically highly significant alterations in the composition of the gut microbiota with increased relative abundance of Lactobacillus, Bifidobacterium and Bacteroidetes and decreased relative abundance of Firmicutes and Firmicutes/ Bacteroidetes Ratio. Conclusion Hypo caloric high fiber regimen diet with probiotics has a positive impact on body composition and is effective for weight loss normalizing serum Leptin and AST. |
