Synthesis, SAR, and Antitumor Properties of Diamino-C,N-diarylpyrimidine Positional Isomers: Inhibitors of Lysophosphatidic Acid Acyltransferase-β

Autor:	Jack W. Singer, Scott A. Jenkins, Rama Bhatt, Peter de Vries, Feng Hong, Baoqing Gong, Peter Klein, Cory Kohm, John Tulinsky
Rok vydání:	2004
Předmět:	Gene isoform chemistry.chemical_compound Biochemistry Chemistry In vivo Stereochemistry Lysophosphatidic acid Structural isomer Structure–activity relationship Tumor cells General Medicine In vitro Lysophosphatidic acid acyltransferase
Zdroj:	ChemInform. 35
ISSN:	1522-2667 0931-7597
Popis:	2,4-Diamino-N(4),6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in vivo tumor model was investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::21b32e1a99d87aff4874fdd50c8a8c7b https://doi.org/10.1002/chin.200435137 Zobrazit plný text záznamu Plný text