Screening extracts of Madagascan plants in search of antiplasmodial compounds

Autor:	Dina L Rakotondramanana, Mehdi Labaied, S. Ratsimamanga-Urverg, Lucile Allorge, Philippe Rasoanaivo, David Ramanitrahasimbola, Philippe Grellier, François Frappier, Lengo Mambu, Herintsoa Rafatro, Armand Rakotozafy, Baholy Robijaona
Rok vydání:	2004
Předmět:	Pharmacology biology Traditional medicine Ethyl acetate Plasmodium falciparum Fractionation Pharmacognosy medicine.disease biology.organism_classification In vitro law.invention chemistry.chemical_compound chemistry law parasitic diseases medicine Phytotherapy IC50 Malaria
Zdroj:	Phytotherapy Research. 18:742-747
ISSN:	0951-418X
Popis:	One hundred and ninety plants, of which 51 are used to treat malaria in traditional medicine, were collected in five different ecosystems of Madagascar for a screening programme devoted to the search of naturally-occurring antimalarial compounds. Thirty-nine plants, of which 12 are used as herbal antimalarials, were found to display in vitro activity against Plasmodium falciparum with a median inhibitory concentration (IC50) lower than 5 microg/ml while 9 had an IC50 ranging from 5 to 7.5 microg/ml. Seventeen of them exhibited cytotoxic effects on murine P388 leukemia cells with an IC50 < 10 microg/ml. The biological activities were mostly located in the ethyl acetate fractions. Bioassay-directed fractionation is underway to isolate the active constituents.
Databáze:	OpenAIRE
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