Autor: |
Dina L Rakotondramanana, Mehdi Labaied, S. Ratsimamanga-Urverg, Lucile Allorge, Philippe Rasoanaivo, David Ramanitrahasimbola, Philippe Grellier, François Frappier, Lengo Mambu, Herintsoa Rafatro, Armand Rakotozafy, Baholy Robijaona |
Rok vydání: |
2004 |
Předmět: |
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Zdroj: |
Phytotherapy Research. 18:742-747 |
ISSN: |
0951-418X |
Popis: |
One hundred and ninety plants, of which 51 are used to treat malaria in traditional medicine, were collected in five different ecosystems of Madagascar for a screening programme devoted to the search of naturally-occurring antimalarial compounds. Thirty-nine plants, of which 12 are used as herbal antimalarials, were found to display in vitro activity against Plasmodium falciparum with a median inhibitory concentration (IC50) lower than 5 microg/ml while 9 had an IC50 ranging from 5 to 7.5 microg/ml. Seventeen of them exhibited cytotoxic effects on murine P388 leukemia cells with an IC50 < 10 microg/ml. The biological activities were mostly located in the ethyl acetate fractions. Bioassay-directed fractionation is underway to isolate the active constituents. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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