High resolution 1H-NMR study on self-complexation phenomena in cyclodextrin dimers

Autor:	Nicolas Birlirakis, Fokke Venema, Benoît Henry, Roeland J. M. Nolte, Patrick Berthault
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Cyclodextrin Chemistry Organic Chemistry Intermolecular force High resolution Temperature a Ring (chemistry) Biochemistry Crystallography Drug Discovery Proton NMR Moiety Linker
Zdroj:	Tetrahedron. 54:3513-3522
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(98)00083-0
Popis:	The unusual conformational behaviour of a series of new cyclodextrin (CD) dimers is studied by dedicated 1H-NMR techniques. In water some CD-dimers form stable self-inclusion complexes, for which the aliphatic linker is partially included in one of the two CD cavities. This phenomenon affects the conformation of the substituted sugar ring of one CD moiety. In the case of the α-β heterodimer, the linker appears to be preferentially in the cavity of β-CD, in contrast to what is known for intermolecular complexes where at ambient temperature a preference for α-CD is observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::21a3ceb2da367f392a9d419b441eb297 https://doi.org/10.1016/s0040-4020(98)00083-0 Zobrazit plný text záznamu Full Text from ScienceDirect