Kinetics of canrenone after single and multiple doses of spironolactone

Autor:	U. Abshagen, K. Koch, E Besenfelder, R. Endele, B. Neubert
Rok vydání:	1979
Předmět:	Pharmacology Chromatography Chemistry Kinetics General Medicine Multiple dosing High-performance liquid chromatography Bioavailability chemistry.chemical_compound Pharmacokinetics medicine Spironolactone Pharmacology (medical) Steady state (chemistry) Canrenone medicine.drug
Zdroj:	European Journal of Clinical Pharmacology. 16:255-262
ISSN:	1432-1041 0031-6970
Popis:	In Study I 20 normal volunteers received a single oral dose of spironolactone 100 mg. In Study II a further 20 normal volunteers were given first spironolactone 100 mg b.i.d. and subsequently spironolactone 100 mg once a day for a further 4 days. In Study III 5 normal subjects were given a single dose of spironolactone 500 mg. The concentration of canrenone in serum was determined both by fluorimetry and HPLC for 0–48 h in Study I, 120–168 h in Study II and 0–36 h in Study III. The total AUCs after the single 100 mg dose did not differ from the AUCs within the dosing interval during steady state. The half-lives of the terminal log-linear phases were almost identical (14.99±0.80 h and 15.69±0,80 h) when determined by fluorimetry, and were sligthly, but significantly (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::219ff5b208e8eb7eb598bea3ee292d6a https://doi.org/10.1007/bf00608404 Zobrazit plný text záznamu Full text from SpringerLink