Urinary CD25 as a Biomarker of Lupus Nephritis Activity in Pediatrics
| Autor: | Eslam S Mobasher, Maher El Shafaei, Mohamed M. A. Salam, Doaa Tawfeek, Nagla A. Khalifa |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Creatinine Proteinuria business.industry Urinary system Group ii Lupus nephritis medicine.disease Gastroenterology chemistry.chemical_compound chemistry immune system diseases Internal medicine medicine Biomarker (medicine) IL-2 receptor medicine.symptom skin and connective tissue diseases business Nephritis |
| Zdroj: | GEGET. 14:82-89 |
| ISSN: | 2636-3658 |
| Popis: | Background Lupus nephritis is one of the most serious manifestations of Systemic lupus erythematosus. Proteinuria, complement level, anti-dsDNA and creatinine are the most widely used to assess activity. Aim of Work The aim of this study was to assess the relationship of urinary s CD25 with lupus nephritis activity as a noninvasive biomarker in children. Patients and Methods The study was conducted on 30 patients divided into 2 groups; Group I: 20 patients of SLE, subdivided into 2 subgroups according to presence of lupus nephritis and Group II: 10 healthy subjects as a control group. Urinary sCD25 was measured in both groups. Results Urinary sCD25 was significantly higher in active LN in comparison to inactive and controls. Urinary s CD25 level was correlated with SLE activity, proteinuria and blood urea. Conclusion Urinary sCD25 is a useful noninvasive technique for assessment of lupus nephritis as it shows a good correlation with some clinical and laboratory parameters of disease relapse. |
| Databáze: | OpenAIRE |
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