Standard clinical practice underestimates the role and significance of erythropoietin deficiency in sickle cell disease

Autor: Stephen Vara, Mohammed Farooqui, Robert E. Molokie, Giovanni Infusino, Santosh L. Saraf, Joseph DeSimone, Yogen Saunthararajah, Seema Sidhwani, Donald Lavelle, Michel Gowhari, Bharvi Oza, Lani Krauz, Weihua Gao
Rok vydání: 2011
Předmět:
Zdroj: British Journal of Haematology. 153:386-392
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2010.08479.x
Popis: Summary In sickle cell disease (SCD), vigorous reticulocytosis is required to partially compensate for chronic hemolytic anaemia. Consequently, early renal damage, insufficient to cause azotemia but sufficient to cause erythropoietin deficiency and chronic relative reticulocytopenia (chRR), could have severe clinical consequences. chRR was defined as reticulocytes
Databáze: OpenAIRE