Standard clinical practice underestimates the role and significance of erythropoietin deficiency in sickle cell disease
Autor: | Stephen Vara, Mohammed Farooqui, Robert E. Molokie, Giovanni Infusino, Santosh L. Saraf, Joseph DeSimone, Yogen Saunthararajah, Seema Sidhwani, Donald Lavelle, Michel Gowhari, Bharvi Oza, Lani Krauz, Weihua Gao |
---|---|
Rok vydání: | 2011 |
Předmět: |
medicine.medical_specialty
Creatinine education.field_of_study Proteinuria Reticulocytosis business.industry Population Hematology medicine.disease Gastroenterology Sickle cell anemia chemistry.chemical_compound chemistry Erythropoietin hemic and lymphatic diseases Internal medicine Immunology medicine Reticulocytopenia Azotemia medicine.symptom business education medicine.drug |
Zdroj: | British Journal of Haematology. 153:386-392 |
ISSN: | 0007-1048 |
DOI: | 10.1111/j.1365-2141.2010.08479.x |
Popis: | Summary In sickle cell disease (SCD), vigorous reticulocytosis is required to partially compensate for chronic hemolytic anaemia. Consequently, early renal damage, insufficient to cause azotemia but sufficient to cause erythropoietin deficiency and chronic relative reticulocytopenia (chRR), could have severe clinical consequences. chRR was defined as reticulocytes |
Databáze: | OpenAIRE |
Externí odkaz: |