| Autor: |
Michael R. D’Agostino, Jann C. Ang, Matthew S. Miller, Ali Zhang, Yonathan Agung, Hanu Chaudhari |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
SummaryThe conserved hemagglutinin stalk domain is an attractive target for broadly effective antibody-based therapeutics and next generation universal influenza vaccines. Protection provided by hemagglutinin stalk binding antibodies is principally mediated through activation of immune effector cells. Titers of stalk-binding antibodies are highly variable on an individual level, and tend to increase with age as a result of increasing exposures to influenza virus. In our study, we show that stalk-binding antibodies cooperate with neuraminidase inhibitors to protect against influenza virus infection in an Fc-dependent manner. These data suggest that the effectiveness of neuraminidase inhibitors is likely influenced by an individual’s titers of stalk-binding antibodies, and that neuraminidase inhibitors may enhance the effectiveness of future stalk-binding monoclonal antibody-based treatments. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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