Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor

Autor:	Hongtao Lu, Feng Ren, David Jonathan Hirst, John D. Elliott, Xichen Lin, Linbo Luan, Taylor B. Guo, Yonghui Wang, Chengyong Li, Ting Yang, Heng Xu, Haibo Zhang, Matthew J Lindon, Wei Zhang, Yan Xu, Jia-Ning Xiang, Han Fangbin, Yonggang Zhao
Rok vydání:	2012
Předmět:	Chemistry Stereochemistry Sphingosine-1-phosphate receptor Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Combinatorial chemistry chemistry.chemical_compound Drug Discovery Molecular Medicine Sphingosine-1-phosphate Receptor Selectivity Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 22:2456-2459
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2012.02.016
Popis:	High-throughput screening of GSK compound collection led to the discovery of a novel series of thiadiazole amides as potent and S1P3-sparing sphingosine-1-phosphate 1 (S1P1) receptor agonists. Synthesis, structure and activity relationship, selectivity, and some developability properties are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::218b1639ff4120b10cb5fb7730ed4a3d https://doi.org/10.1016/j.bmcl.2012.02.016 Zobrazit plný text záznamu Full Text from ScienceDirect