Efficient synthesis of N′-benzylidene-2-hydroxymethylbenzohydrazides from the one-pot reaction of phthalide, hydrazine and aldehydes

Autor:	Zulipiye Alifu, Keyume Ablajan, Maijidan Nizhamu
Rok vydání:	2019
Předmět:	chemistry.chemical_classification Ethanol 010405 organic chemistry Hydrazine General Chemistry 010402 general chemistry 01 natural sciences Aldehyde Environmentally friendly 0104 chemical sciences Phthalide Catalysis chemistry.chemical_compound chemistry Organic chemistry Hydroxymethyl Hydrate
Zdroj:	Research on Chemical Intermediates. 45:4779-4788
ISSN:	1568-5675 0922-6168
DOI:	10.1007/s11164-019-03863-8
Popis:	We report an efficient, catalyst-free, one-pot synthesis of (E)-N′-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives by the one-pot reaction of phthalide, hydrazine hydrate and aldehyde. Advantages of this synthetic approach include mild reaction conditions and environmentally friendly nature, and the ability to provide a wide range of desired compounds in moderate to excellent yields. Here we introduce a green and efficient one-pot three-component protocol for the synthesis of (E)-N′-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives in ethanol without any catalyst.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2186b80e56512efc5c48304871897ab3 https://doi.org/10.1007/s11164-019-03863-8 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.