Syntheses and fungicidal activities of thiazole-5-carboxanilides bearing thioether group
| Autor: | Mingzhi Huang, Jiao Ye, Aiping Liu, Xue Hansong, Yeguo Ren, Li Jianming, Xiaoming Ou, Lian He, Liu Weidong, Lu Huang |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Trifluoromethyl biology 010405 organic chemistry Carboxylic acid General Chemistry 010402 general chemistry biology.organism_classification 01 natural sciences 0104 chemical sciences Rhizoctonia solani chemistry.chemical_compound Aniline chemistry Thioether Structure–activity relationship Organic chemistry Thiazole Lead compound |
| Zdroj: | Chemical Research in Chinese Universities. 32:781-785 |
| ISSN: | 2210-3171 1005-9040 |
| DOI: | 10.1007/s40242-016-6153-z |
| Popis: | In an attempt to find leading thiazole carboxanilides exhibiting fungicidal activities, we designed and synthesized a new series of 2-sulfursubstituted thiazole carboxanilides via the reaction between 2-sulfur substituted thiazole carboxylic acid chlorides and substituted aniline. The fungicidal activities of the title compounds against Rhizoctonia solani were screened and the results were remarkable. The most potent compound 8i, N-[2,6-dichloro-4-(trifluoromethyl)phenyl]-2-methylthio-4-(trifluoromethyl)thiazole-5-carboxamide, was identified. The fungicidal EC50 of compound 8i against Rhizoctonia solani was 1.28 mg/L, being comparable to that of Thifluzamide. The results indicate that compound 8i can be considered as a lead compound for further research. |
| Databáze: | OpenAIRE |
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