Restoration of Patency to Central Airways Occluded by Malignant Endobronchial Tumors Using Intratumoral Injection of Cisplatin

Autor:	Michael A. Jantz, Abbie Begnaud, Paras Malhotra, Sebastian Fernandez-Bussy, Hiren J. Mehta, Jonathan J. Shuster, John Wynne, Jessica Cope, Andrea M. Penley
Rok vydání:	2015
Předmět:	Pulmonary and Respiratory Medicine Cisplatin medicine.medical_specialty Performance status business.industry Histology Airway obstruction medicine.disease Surgery Quality of life medicine business Lung cancer Adverse effect Airway medicine.drug
Zdroj:	Annals of the American Thoracic Society. 12:1345-1350
ISSN:	2325-6621 2329-6933
DOI:	10.1513/annalsats.201503-131oc
Popis:	Rationale: Malignant airway obstruction is commonly found in patients with lung cancer and is associated with significant morbidity and mortality. Relieving malignant obstruction may improve symptoms, quality of life, and life expectancy.Objectives: The objective of this study was to analyze our experience with bronchoscopic endobronchial intratumoral injection of cisplatin for malignant airway obstruction.Methods: We conducted a retrospective analysis of patients with malignant airway obstruction treated with bronchoscopic intratumoral injection of cisplatin. Patient characteristics, histology, degree of airway obstruction, procedural methods, treatment cycles, performance status, and therapeutic outcomes were evaluated. Tumor response was analyzed based on bronchoscopic measurements performed on completion the of final treatment session. Adverse events and overall survival were abstracted.Measurements and Main Results: Between January 2009 and September 2014, 22 patients (10 men, 12 women; mean age ± SD...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::217e505fedb561de409abece4e33b919 https://doi.org/10.1513/annalsats.201503-131oc Zobrazit plný text záznamu