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Static blood (SB) is a traditional Korean medicine disease symptom caused by a blood amassment, which refers to a pathological product of blood circulating poorly or accumulating in the interior. The growth and denaturalization of various organizations, inflammatory response and blood circulation disorder are regarded pathological conditions of SB. Endometrial hyperplasia (EH) is a state of excessive proliferation of the cells of the endometrium. Therefore, we suggest the EH mouse model as the experimental animal model of SB. Keywords static blood, traditional Korean medicine, experimental animal model, endometrial hyperplasia Static blood (SB) in traditional Korean medicine (TKM) SB is a pathological product of blood stagnation, including extravasated blood and the blood circulating sluggishly or blood congested in a viscus, all of which may turn into pathogenic factor, the same as blood stasis or stagnant blood. Major causes of SB are a blood heat, blood cold and bleeding caused by traumatic injury or others. Many classic medicine books introduced the symptoms of the SB are as follows; Pain (疼痛) (血證論, Tang rong chuan, 1884), chills (惡寒), fever (發熱), and alternating chills and fever (寒熱往來) (血證論, 名醫指掌·瘀血篇; 金匱要略, 婦人産後病篇, 婦人雜病篇, Zhang zhong jing, 217), abdomen fullness (腹部硬滿) (金匱要略, 驚悸吐衄篇; 讀醫隨筆, Zhou xue hai, 瘀血內熱, 1891), abdomen aggregation-accumulation (腹部積聚) (黃帝內經, Huang di, 168 BC), manic psychosis (發狂), depressive psychosis (癲狂), forgetfulness (善忘, 健忘) (傷寒論, Zhang zhong jing, 217; 諸病源候論, 卒被損瘀血候篇, Chao yuan fang, 610), thirst(口渴) (金匱要略, 驚悸吐衄下血胸滿瘀血病脈證治), bluish purple tongue and lip (靑紫舌), encrusted skin (肌膚甲錯) (諸病源候論, 卒被損瘀血候篇), etc. Although SB is a pathological product, formed SB causes various diseases including neuropsychiatric disorders (Kim, 2001), cardiovascular system disorder, musculoskeletal disorder (Lee et al., 2007), and obstetrics and gynecology diseases by disturbing blood circulation (Nam et al., 2006). Furthermore, the abnormal growth and denaturalization of various organizations and inflammatory response are regarded pathological conditions of SB. |
