Probiotics as a Dietary Intervention for Reducing the Risk of Nonalcoholic Fatty Liver Disease
| Autor: | Harsh Panwar, Namita Rokana, Fouad M. F. Elshaghabee, Knut J. Heller, Jürgen Schrezenmeir |
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| Rok vydání: | 2019 |
| Předmět: |
Liver injury
medicine.medical_specialty Triglyceride biology business.industry Saturated fat Gut flora medicine.disease biology.organism_classification digestive system chemistry.chemical_compound Liver disease Endocrinology chemistry Internal medicine Nonalcoholic fatty liver disease Lipogenesis medicine Metabolic syndrome business |
| Zdroj: | Environmental Chemistry for a Sustainable World ISBN: 9783030046743 |
| DOI: | 10.1007/978-3-030-04675-0_8 |
| Popis: | Nonalcoholic fatty liver disease (NAFLD) is characterized by an increase in triglyceride fat content of liver cells without excessive consumption of alcohol. It is the most predominant liver disease among different age groups including children and adults. Unhealthy foods such as high fructose and high trans-fatty acids in saturated fat seem to be associated with the pathogenesis of NAFLD. Different clusters of gut microbiota, e.g., Firmicutes, could regulate the energy balance and fat storage. Furthermore, different metabolites of gut microbiota, for example, endogenous short chain fatty acids and ethanol, are associated with increased levels of lipogenesis. Additionally, metabolism of endogenous ethanol leads to the formation of acetaldehyde resulting in increased oxidative stress and ultimately inducing liver injury. Lipopolysaccharides of the outer membrane of Gram-negative gut bacteria may also initiate some low grade inflammation in liver tissues. However, few reports from NAFLD patients showed ordinary serum endotoxin levels, excluding endotoxemia from the pathogenesis of NAFLD. |
| Databáze: | OpenAIRE |
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