ChemInform Abstract: Enantioselective Syntheses of Homophenylalanine Derivatives via Nitrone 1,3-Dipolar Cycloaddition Reactions with Styrenes

Autor:	Steven W. Baldwin, Alan Long
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Hydrogenolysis Chemistry 1 3-Dipolar cycloaddition Glycine Enantioselective synthesis General Medicine Medicinal chemistry Cycloaddition Styrene Nitrone
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200144204
Popis:	A new two-step route to derivatives of homophenylalanine is presented. Cycloaddition of a cyclic nitrone glycine template with various styrene derivatives affords good yields of 5-substituted cycloadducts. One-step hydrogenolysis (three bonds) then affords the optically pure α-amino acids related to homophenylalanine.
Databáze:	OpenAIRE
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