Decreased Global Myocardial Work Efficiency Correlates with Coronary Vasculopathy in Pediatric Heart Transplant Patients
| Autor: | Shelly Stark, Justin T. Tretter, Anna Mullikin, Nicholas J. Ollberding, Huaiyu Zang, Clifford Chin, Garick D. Hill, Sarah Pradhan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Heart transplantation
medicine.medical_specialty Ejection fraction genetic structures business.industry medicine.medical_treatment Work efficiency Vascular surgery Cardiac surgery medicine.anatomical_structure Ventricle Internal medicine Pediatrics Perinatology and Child Health cardiovascular system Cardiology Medicine Derivation Cardiology and Cardiovascular Medicine business Cardiac catheterization |
| Zdroj: | Pediatric Cardiology. 43:515-524 |
| ISSN: | 1432-1971 0172-0643 |
| DOI: | 10.1007/s00246-021-02748-1 |
| Popis: | Coronary angiography remains the standard for diagnosis of cardiac transplant vasculopathy (CAV), but it is invasive. Non-invasively derived left ventricle (LV) global myocardial work (GMW) indices have not been evaluated. We aimed to assess for correlations between LV GMW and the presence of CAV in a pediatric population. 24 heart transplant patients and 24 normal controls were prospectively enrolled. Patients were age-matched into groups with: orthotopic heart transplant and CAV (OHT-CAV; 6 patients, 33% male, mean age 13.5 years [SD 4.2]), orthotopic heart transplant without CAV (OHT; 18 patients, 67% male, mean age 11.1 years [SD 4.8]), and normal healthy controls (42% male, mean age 12.8 years [SD 5.0]). Transplant patients underwent cardiac catheterization with coronary angiography within 3 months of echocardiogram. Post-processing of echocardiograms with speckle-tracking echocardiography and derivation of GMW indices was performed. OHT-CAV patients had decreased global work efficiency (GWE) compared to OHT (mean difference = 7.01 [1.76, 12.25], adjusted p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink