Synthesis and Biological Activity of 8-(Dialkylamino)-3-aryl-6-oxo-2,4-dicyanobicyclo[3.2.1]octane-2,4-dicarboxylic Acids Diethyl Esters

Autor:	M. Shoaib, A. A. Israilova, A. M. Magerramov, Victor V. Dotsenko, A. I. Ismiyev, Khudaverdi Ganbarov
Rok vydání:	2020
Předmět:	chemistry.chemical_classification integumentary system Bicyclic molecule 010405 organic chemistry Aryl Biological activity General Chemistry 010402 general chemistry Furfural Antimicrobial 01 natural sciences Aldehyde 0104 chemical sciences chemistry.chemical_compound chemistry Cascade reaction Organic chemistry Octane
Zdroj:	Russian Journal of General Chemistry. 90:1418-1425
ISSN:	1608-3350 1070-3632
Popis:	Cascade reaction of 2 equiv. of furfural (or equimolar amounts of furfural and aromatic aldehyde) with secondary amines and ethyl cyanoacetate afforded diethyl esters of 8-(dialkylamino)-3-aryl-6-oxo-2,4-dicyanobicyclo[3.2.1]octane-2,4-dicarboxylic acids with yields of 37–54%. Antimicrobial activity of a number of obtained compounds in vitro was studied, and biological activity in silico was analyzed. The obtained bicyclo[3.2.1]octanes are inactive or exhibit weak fungicidal activity, but exhibit moderate bactericidal effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::215d12fa5b156b545a85c313abdbbd88 https://doi.org/10.1134/s1070363220080071 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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