Hochauflösende T1-gewichtete MR-Lymphographie inguinaler Lymphknoten nach interstitieller Applikation von Gadomer-17 im Tierexperiment

Autor:	E. Spüntrup, Arno Bücker, Bernd Klosterhalfen, Bernd Misselwitz, R. W. Günther, D. Pflüger, Gundula Staatz
Rok vydání:	2005
Předmět:	medicine.medical_specialty business.industry Inguinal lymph nodes Body weight Lymphatic system medicine.anatomical_structure Coronal plane Parenchyma medicine Surface coil Radiology Nuclear Medicine and imaging Lymph Radiology Nuclear medicine business Lymph node
Zdroj:	RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren. 177:968-974
ISSN:	1438-9010 1438-9029
Popis:	PURPOSE To evaluate the microstructural anatomy of inguinal lymph nodes in pigs after interstitial MR-lymphography with the dendritic contrast agent Gadomer-17. MATERIAL AND METHODS High-resolution T1-weighted MR-lymphography was performed in inguinal lymph nodes of 10 domestic pigs (39 - 46 kg) after subcutaneous injection of 10 mumol/kg body weight Gadomer-17 in the hind legs of the animals. A 1.5T MR scanner and a ring-shaped surface coil were used. Two different high-resolution gradient-echo sequences with additionally reconstructed maximum-intensity projections were evaluated in a total of 20 lymph nodes. The high-resolution MR-findings were correlated with the histologic sections of the excised inguinal lymph nodes. RESULTS Coronal T1-weighted 3D gradient-echo images (TR = 20 msec, TE = 6.1 - 8.3 msec, FA = 20 degrees ) with a slice thickness of 1 mm, a field-of-view of 120 mm and a matrix size of 256 x 256 (reconstructed to 1024 x 1024 voxels) yielding a reconstructed in-plane resolution of 117 x 117 microm (2) were best suited for the high-resolution MR lymphography of inguinal lymph nodes and enabled the differentiation of the hyperintense lymph node sinuses and hypointense lymphoid parenchyma of each lymph node (100 %). Even dilated lymphatic vessels evident in the histologic specimen were best demonstrated on the MIP images. CONCLUSION High-resolution interstitial MR lymphography with Gadomer-17 allows the visualization of different tissue compartments of inguinal lymph nodes. This new technique is feasible on a routine 1.5T scanner and may offer potential for the detection of micrometastases in lymph nodes of cancer patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::215abc59ae0a4a99c97192203be2094a https://doi.org/10.1055/s-2005-858239 Zobrazit plný text záznamu