Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents

Autor:	Alla Pavlova, E. V. Nazimova, O. V. Ardashov, Nariman F. Salakhutdinov, Irina V. Il'ina, Oksana S. Mikhalchenko, Dina V. Korchagina, Konstantin P. Volcho, T. G. Tolstikova, Ekaterina A. Morozova
Rok vydání:	2016
Předmět:	010405 organic chemistry Stereochemistry Diol Analgesic Substituent Plant Science General Chemistry 010402 general chemistry Ring (chemistry) 01 natural sciences In vivo tests General Biochemistry Genetics and Molecular Biology 0104 chemical sciences chemistry.chemical_compound chemistry Thiophene
Zdroj:	Chemistry of Natural Compounds. 52:813-820
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-016-1785-2
Popis:	Hexahydro-2H-chromenes with thiophene fragments were synthesized via reactions of a p-menthane monoterpenoid diol with several thiophenecarboxaldehydes. Most of the synthesized compounds with an additional thiophene fragment displayed analgesic activity in vivo tests at a dose of 10 mg/kg. It was found that the activity in either an acetate-writhing test or a hot-plate test depended on the type and location of substituent in the heteroaromatic ring.
Databáze:	OpenAIRE
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