Ermittlung der optimalen L-Thyroxin-Dosis zur Behandlung der blanden Struma

Autor:	Albrecht W, H.-J. Biersack, C. Winkler, P. Oehr, A. Rasche
Rok vydání:	2008
Předmět:	Body surface area medicine.medical_specialty TRH stimulation test Endocrinology business.industry Internal medicine Medicine General Medicine business Goitre size Hormone Nontoxic goiter
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 108:1269-1273
ISSN:	1439-4413 0012-0472
Popis:	303 patients with non-toxic goitre (aged 14-85 years) were studied to determine the extent to which the level of thyroid-hormone dosage until a negative TRH test is reached can be defined in terms of age, body surface area and goitre size. In all instances detailed examination had determined regular hormone intake. The required L-thyroxine dose (until negative TRH test) was 100 micrograms/d in 75.6% of cases, 125 micrograms/d in 9.2% and 150 micrograms/d in 8.6% of cases. In 2.6% of cases was a satisfactory suppression reached at 50 microgram/d and in 4% at 75 micrograms/d. There was no correlation of the level of L-thyroxine dose to body surface area, age, T3 level, delta-TSH or goitre size. There was a slight correlation between T4 level and optimal L-thyroxine dose, but not significant because of the wide range of normal. The results indicate that the only way to obtain optimal L-thyroxine dosage in the treatment of goitre is by doing a TRH test in the given patient.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::21544545a6b5a87bcb61ae7af1354eb5 https://doi.org/10.1055/s-2008-1069733 Zobrazit plný text záznamu