Abstract 3865: Targeting the epigenetic modifier HMGA2 in lethal adult and pediatric gliomas inhibits invasion, growth and tumorigenicity
| Autor: | Eric H. Raabe, Fausto J. Rodriguez, Sepehr Akhtarkhavari, Charles G. Eberhart, Harpreet Kaur, Huizi Guo, Sabeen Z. Ali |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Cancer Research. 77:3865-3865 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.am2017-3865 |
| Popis: | Glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG) are highly infiltrative, incurable adult and pediatric brain tumors characterized by the presence of tumor stem-like cells. Although GBM and DIPG have different epigenetic drivers, we found increased expression of an epigenetic modifier and stem cell factor HMGA2 in both tumors by immunohistochemistry and western blotting. HMGA2 is a DNA-binding protein that regulates transcription during normal embryogenesis and in cancer stem cells. We hypothesized that HMGA2 contributes to high grade glioma tumorigenicity through its ability to alter the transcription of many genes. Lentiviral short hairpin RNA (shRNA)-mediated reduction of HMGA2 in multiple patient-derived GBM cell lines significantly reduced invasion in transwell assay (shHMGA2 vs. shControl, P Citation Format: Harpreet Kaur, Sabeen Z. Ali, Huizi Guo, Sepehr Akhtarkhavari, Fausto Rodriguez, Charles G. Eberhart, Eric H. Raabe. Targeting the epigenetic modifier HMGA2 in lethal adult and pediatric gliomas inhibits invasion, growth and tumorigenicity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3865. doi:10.1158/1538-7445.AM2017-3865 |
| Databáze: | OpenAIRE |
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