Autor: Jerome H. Check, Youval Katz, Parvin Nazari, Matthew L. Check, Julia Szekeres-Bartho
Rok vydání: 2001
Předmět:
Zdroj: Journal of Assisted Reproduction and Genetics. 18:603-607
ISSN: 1058-0468
DOI: 10.1023/a:1013113022336
Popis: Purpose: To determine if production of the immunomodulatory protein, progesterone induced blocking factor (PIBF), requires merely progesterone or whether other factors made by the corpus luteum are required. Methods: The percentage of peripheral lymphocytes expressing PIBF was determined by obtaining a blood sample from women 9–12 days after embryo transfer. The embryos were either fresh ones following hyperstimulation and oocyte retrieval or were frozen-thawed embryos. Preparation for frozen embryo transfer required corpus luteum suppression with exogenous estrogen. The percentage of lymphocytes expressing PIBF was determined by an immunocytochemistry method. Results: PIBF expression (>1%) was found in 20.5% of COH and 13.3% of frozen embryo transfer cycles. There either was a significant difference or a trend for higher pregnancy rates when PIBF expression was detected. Conclusions: These data corroborate previous conclusions that PIBF is detected in a minority of women in the late luteal phase. A corpus luteum is not required for its expression.
Databáze: OpenAIRE
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