Novel complexes of tris(aminomethyl)phosphanes with platinum(II): Structural, spectroscopic, DFT and biological activity studies
| Autor: | Radosław Starosta, Maciej Barys, A. Wieliczko, Aleksandra Bykowska, Zdzisław Staroniewicz, Małgorzata Jeżowska-Bojczuk |
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| Rok vydání: | 2011 |
| Předmět: |
Tris
Circular dichroism education.field_of_study Quenching (fluorescence) Ligand Chemistry Stereochemistry Population chemistry.chemical_element Time-dependent density functional theory Inorganic Chemistry chemistry.chemical_compound Crystallography Materials Chemistry Physical and Theoretical Chemistry Luminescence Platinum education |
| Zdroj: | Polyhedron. 30:2914-2921 |
| ISSN: | 0277-5387 |
| DOI: | 10.1016/j.poly.2011.08.027 |
| Popis: | Two new platinum(II) complexes with tris(aminomethyl)phosphanes: [ trans -PtCl 2 {P(CH 2 N(CH 2 CH 2 ) 2 NCH 3 ) 3 } 2 ] ( 1Pt ) and [ trans -PtCl 2 {P(CH 2 N(CH 2 CH 2 ) 2 O) 3 } 2 ] ( 2Pt ) were prepared and characterized with NMR and UV–Vis spectroscopies. Their structures were investigated by X-ray crystallography and DFT methods. TDDFT calculations were employed to interpret the electronic spectra of the complexes. Obtained results are not unequivocal, however population analysis indicate, that the character of HOMO and HOMO−1 orbitals depend strongly on the electron donoring properties of the phosphane ligand. Biological activity of 2Pt complex, which is more stable and more soluble in polar solvents than 1Pt , was examined in vitro on the Vero cell line (IC 50 = 12.5 μM). At higher concentrations it induces apoptosis, probably due to changes of the cell cytoskeleton. Luminescence quenching studies and CD spectroscopy of interactions of 2Pt with HSA and BSA indicate that these albumins bind the complex slightly – without altering their tertiary structures, however HSA interacts with 2Pt noticeably stronger than BSA. It was also found that 2Pt does not cleave supercoiled pUC18 plasmid. |
| Databáze: | OpenAIRE |
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