Application of BI-V for contact children and adolescents from focies of multidrug-resistant tuberculous infection: evaluation of effectiveness
| Autor: | M.I. Sakhelashvili, Z.I. Piskur, O.I. Sakhelashvili–Bil, J.J. Didyk, Yu.O. Letz, G.S. Matseh, M.R. Davydiv, O.S. Yakimchuk, L.S. Ilnytska, N.B. Shepta, O.L. Sosnova |
|---|---|
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Tuberculosis, Lung Diseases, HIV Infection. :37-43 |
| ISSN: | 2522-1094 2220-5071 |
| DOI: | 10.30978/tb-2023-1-37 |
| Popis: | Objective — to study the need of using the natural immunomodulator ВІ-V for contact children and adolescents from focies of multidrug-resistant tuberculous infection (MDR-TBI) for a non-specific immunoprevention of tuberculosis (TB). Materials and methods. A retrospective analysis of the medical records of 120 contacts (75 children and 45 adolescents) from focies of MDR-TBI and 102 adult with TB, who became the source of infection was carried out. Microbiological examination in adults included the detection of Mycobacterium tuberculosis (MBT) in sputum by smear microscopy, sowing of material on Levenstein—Jensen medium, typing of isolated MBT on BACTEC MGIT 960, determination of the drug susceptibility test (DST) of MBT to antimycobacterial drugs (AMBDs) of first- and second-line, as well as molecular genetic researched of sputum, in particular by the method of GeneXpert MTB/RIF and linear probe analysis. In the contact children from focies of MDR-TBI the determination of the population and subpopulation composition of blood lymphocytes was carried out among 25 children before and among 22 children after immunoprevention. Results and discussion. Most contact children and adolescents (61.7 %) from focies of MDR-TBI had concomitant diseases. The prophylactic administration of the BI-V immunomodulator reduced the frequency of acute respiratory viral infections and exacerbations of non-specific bronchopulmonary diseases by 2.0 times, the development of an active process from the latent tuberculous infection by 2.6 times, the frequency of transformation of latent tuberculosis infection into an active process by 2.6 times, improved appetite, memory, learning outcomes and increased physical activity. The latent tuberculous infection based on the Mantoux test results was found in 82.5 % (99) children. The quantiferon test confirmed the presence of a latent form of tuberculosis in 104 (86.7 %) contacts, the rest of the test results were negative. In children who received ВІ-V, latent tuberculous infection turned into an active process 2.8 times less often than in infected children who did not take this immunomodulator. The existing deviations into the regulatory system and the cellular response system disappeared after the autumn-spring course of ВІ-V. Conclusions. Immunomodulator ВІ-V is an effective preventive means for bronchopulmonary diseases, including MDR-TB among contact children and adolescents from focies of MDR-TBI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|