G1 heavy chain disease clinicopathological, ultrastructural and immunochemical study of a new case

Autor:	Renato Coda, E. Leonardo, Roberto Navone, Aldo Stramignoni, A Carbonara, W Paolino
Rok vydání:	1980
Předmět:	Cancer Research Pathology medicine.medical_specialty Endoplasmic reticulum General Medicine Biology medicine.disease Heavy chain disease medicine.anatomical_structure Oncology medicine Ultrastructure Immunoglobulin heavy chain Immunohistochemistry Bone marrow Lymph Reticulum
Zdroj:	Journal of Cancer Research and Clinical Oncology. 96:93-103
ISSN:	1432-1335 0171-5216
DOI:	10.1007/bf00412900
Popis:	Clinicopathological ultrastructural, and immunohistochemical findings of a new case of IgG1 heavy chain disease are reported in detail. The abnormal protein lacks the VH and CH1 region with sequence starting at 225 residue. The main pathologic feature was plasmacytic tumor of the lymph nodes with B-cell immunoblastic sarcoma patterns. Neoplastic diffusion to other organs was also present. Plasmacytic neoplastic cells have also been found in the bone marrow. The ultrastructure of the noeplastic cells was characterized by more or less abundant plasmacytic-like endoplasmic reticulum with very frequent peculiar whorled configurations. Immunohistochemical methods revealed the abnormal protein production by neoplastic cells in different stages of differentiation. From this case and from the data of the literature it is concluded that the gamma HCD is due to a neoplastic proliferation of lymphoplasmacytic cells whereas the reticulum cells are never involved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2135e5aa9bc15d5fb925774ea7b38108 https://doi.org/10.1007/bf00412900 Zobrazit plný text záznamu Full text from SpringerLink