Changes in some parameters of immune response under the effect of adrenoceptor blockers
| Autor: | A. P. Babenko, E. Yu. Sherstoboev, N. V. Masnaya, O. S. Borsuk |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Adrenergic receptor business.industry Stimulation General Medicine Propranolol Pharmacology Dihydroergotamine General Biochemistry Genetics and Molecular Biology Endocrinology Immune system Immunization Antigen Internal medicine medicine business After treatment medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 143:81-85 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-007-0086-y |
| Popis: | We studied the effect of α-and β-adrenoceptor blockers on humoral and cell immune response in (CBA×C57Bl/6)F1 mice under normal conditions and during stress. The suppressive effect of α-adrenoceptor blocker dihydroergotamine on humoral immune response against the background of both immunization and combined effects of immobilization and injection of a thymus-dependent antigen was more pronounced compared to that of β-adrenoceptor blocker propranolol. Dihydroergotamine suppressed proliferative activity of T cells, stimulated proliferation of B cells at late terms after immunization, but inhibited it against the background of stress and antigen treatment. Propranolol stimulated proliferative activity of T and B cells at early terms after both immunization alone and stress with antigen treatment, but decreased the proliferation stimulation index of lymphoid cells at late terms after treatment (days 7–10). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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