Arterial 18F-Fluorodeoxyglucose Uptake Reflects Balloon Catheter-Induced Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions
| Autor: | Yan Zhao, Chihiro Koshimoto, Nagara Tamaki, Yunosuke Matsuura, Yujiro Asada, Nozomi Okuyama, Yuji Kuge, Keiichi Kawai, Songji Zhao, Takashi Iwakiri, Atsushi Yamashita, Kazuyo Ohe, Chihiro Sugita |
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| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test biology business.industry Balloon catheter Thrombogenicity General Medicine medicine.disease Balloon Magnetic resonance angiography Fibrin Tissue factor medicine.anatomical_structure medicine biology.protein Thrombus Cardiology and Cardiovascular Medicine Nuclear medicine business Artery |
| Zdroj: | Circulation Journal. 77:2626-2635 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-12-1463 |
| Popis: | Background: Imaging modalities to assess atherosclerotic plaque thrombogenicity have not been established, so in this study the relationship between [18F]-fluorodeoxyglucose (18F-FDG) uptake and thrombus formation was investigated in rabbit atherosclerotic arteries. Methods and Results: Atherosclerotic plaque was induced in the iliacofemoral artery by balloon injury and a 0.5% cholesterol diet. At 3 weeks after the first balloon injury, the arteries were visualized by 18F-FDG positron emission tomography (PET) imaging 2h after an 18F-FDG infusion, and then arterial thrombus was induced by a second balloon injury of both iliacofemoral arteries. Imaging with 18F-FDG-PET revealed significantly more radioactivity along the injured (0.63±0.12 SUVmax), than the contralateral non-injured artery (0.34±0.08 SUVmax, n=17, P |
| Databáze: | OpenAIRE |
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