Photodynamic therapy and nuclear imaging activities of zinc phthalocyanine-integrated TiO2 nanoparticles in breast and cervical tumors
| Autor: | Cumhur Gündüz, Kasim Ocakoglu, Suleyman Gokhan Colak, Fatma Yurt, Cansu Caliskan Kurt, Cigir Biray Avci, Hale Melis Soylu, Ozge Er, Mine Ince |
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| Rok vydání: | 2017 |
| Předmět: |
Nuclear imaging
medicine.medical_treatment Nanoparticle Photodynamic therapy 02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences Biochemistry HeLa Drug Discovery medicine Photosensitizer Cytotoxicity Pharmacology biology Chemistry Organic Chemistry 021001 nanoscience & nanotechnology biology.organism_classification In vitro 0104 chemical sciences Cell culture Cancer research Molecular Medicine 0210 nano-technology |
| Zdroj: | Chemical Biology & Drug Design. 91:789-796 |
| ISSN: | 1747-0277 |
| Popis: | In recent years, phthalocyanines (Pcs) have been widely used as photosensitizer in photodynamic therapy applications. Because of their strong absorptions in the near-infrared region (640-700 nm). The integration of phthalocyanine derivatives to a nanoparticle is expected to be efficient way to improve the activity of the photosensitizer on the targeted tissue. It is known that the integrated molecules not only show better accumulation on tumor tissue but also reduce toxicity in healthy tissues. In this study, the ZnPc molecule was synthesized and integrated to the TiO2 nanoparticle, to investigate the potential of PDT and its cytotoxicity. Additionally, ZnPc and ZnPc-TiO2 molecules were labeled with 131 I and it was aimed to put forth the nuclear imaging/therapy potentials of 131 I labeled ZnPc/ZnPc-TiO2 by determining in vitro uptakes in mouse mammary carcinoma (EMT6), human cervical adenocarcinoma (HeLa). In result of our study, it was observed that the radiolabeling yields of the synthesized ZnPc and ZnPc-TiO2 with 131 I were quite high. In vitro uptake studies shown that 131 I-ZnPc-TiO2 could be a potential agent for nuclear imaging/treatment of breast and cervical cancers. According to PDT results, ZnPc-TiO2 might have as to be a potential PDT agent in the treatment of cervical tumor. ZnPc and ZnPc-TiO2 might be used as theranostic agents. |
| Databáze: | OpenAIRE |
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