Synthesis of bis-furyl-pyrrolo[3,4-b]pyridin-5-ones via Ugi–Zhu reaction and in vitro activity assays against human SARS-CoV-2 and in silico studies on its main proteins

Autor:	Ivette Morales-Salazar, Flora P. Montes-Enríquez, Carlos E. Garduño-Albino, M. A. García-Sánchez, Ilich A. Ibarra, Yareli Rojas-Aguirre, Montserrat Elemi García-Hernández, Rosa Elena Sarmiento-Silva, Sofía Lizeth Alcaraz-Estrada, Erik Díaz-Cervantes, Eduardo González-Zamora, Alejandro Islas-Jácome
Rok vydání:	2023
Předmět:	Pharmacology Organic Chemistry Drug Discovery Pharmaceutical Science Molecular Medicine Biochemistry
Zdroj:	RSC Medicinal Chemistry. 14:154-165
ISSN:	2632-8682
DOI:	10.1039/d2md00350c
Popis:	Six polyheterocycles were studied in vitro against human SARS-CoV-2 finding that one of them exhibited significant activity at initial infection stages, showing prophylactic potential. A second one showed both, prophylactic and therapeutic activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::212470d466ff6fccd9a3b3f8516d6ee6 https://doi.org/10.1039/d2md00350c Zobrazit plný text záznamu