Activation of serotonin 5-HT7 receptor induces coronary flow increase in isolated rat heart
| Autor: | Ching-Chia Chang Chien, Ling-Wei Hsin, Ming-Jai Su |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology business.industry medicine.drug_class Hydrochloride Receptor antagonist Nitric oxide 5-HT7 receptor Nitric oxide synthase chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine biology.protein Medicine Serotonin business 5-HT receptor Artery |
| Zdroj: | European Journal of Pharmacology. 748:68-75 |
| ISSN: | 0014-2999 |
| Popis: | Serotonin (5-Hydroxytryptamine, 5-HT) can elicit both vasoconstrictive and relaxant responses on rat coronary artery. The constrictive response has been well discussed, but the mechanism of relaxant response is less studied. In the present study, we found serotonin (0.3 and 1 μM) increased coronary flow on isolated rat hearts, and treatment of nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) 300 μM reduced but not totally blocked this coronary flow increasing effect. In L-NAME 10 μM treated heart, treatment of selective serotonin 5-HT₇ receptor antagonist SB269970 0.1 μM blocked serotonin induced coronary flow increasing response, and in the presence of 1 μM SB269970, serotonin turned into reducing coronary flow. Treatment of TCW295 (8-(2,4-Dimethoxyphenyl)-6-methoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol hydrochloride), a novel serotonin 5-HT₂A/₇ receptor antagonist, inhibited both serotonin induced coronary flow increasing and decreasing effects. In conclusion, we found serotonin increases coronary flow of isolated rat heart by activating serotonin 5-HT₇ receptor activation, and this effect can be, at least partially, resistant to L-NAME. |
| Databáze: | OpenAIRE |
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