Epidemiologische Untersuchung zur Erkennung der präklinischen Phase des Typ-I-Diabetes bei Schulkindern*
| Autor: | Hans Hauner, Werner A. Scherbaum, A. Fetzer, M. Glück, J. Seissler, N. Yassin, U. Speck, Stefan R. Bornstein, Eberhard Heinze |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Glucose tolerance test
medicine.medical_specialty Percentile medicine.diagnostic_test biology business.industry Insulin medicine.medical_treatment Autoantibody General Medicine medicine.disease Endocrinology Diabetes mellitus Internal medicine Insulin response cardiovascular system medicine biology.protein Antibody business Early phase |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 115:689-694 |
| ISSN: | 1439-4413 0012-0472 |
| Popis: | Sera of 4208 schoolchildren in Ulm and surrounding areas (1916 boys, 2292 girls; mean age 13.9 [7-21] years) were analysed for the presence of cytoplasmatic islet-cell antibodies (ICA). ICA were demonstrated in 44 children (1.05%). Complement-fixing ICA (CF-ICA) were found in six of them, insulin autoantibodies (IAA) in seven. The early phase of insulin response in the intravenous glucose tolerance test was below the 1st percentile of normal controls in two of the ICA-positive children. In the course of the subsequent 6-9 months the ICA disappeared in half of the previously positive children. In the two with abnormal glucose tolerance tests ICA, CF-ICA and abnormal insulin secretion persisted during the observation period of 9 months. In another CF-ICA-positive schoolchild insulin response to the glucose tolerance test fell below the 1st percentile after 6 months. These results indicate that, even in an unselected group of children, persisting ICA and CF-ICA are high-risk markers for abnormal insulin secretion, which precedes the onset of type I diabetes. |
| Databáze: | OpenAIRE |
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