Preparation of Single Crystal of Inosine Induced by Sulfosalicylic Acid

Autor: Yunan Zhang, Guangdong Cheng, Yingli Liu, Xin Su, Liang Chang, Yunjie Zhang, Yanru Feng, Dongyu Zou, Xue-song Zhang, Lixin Liu, Lili Wu, Chaoxing Wang, Lei Zhang
Rok vydání: 2020
Předmět:
Zdroj: Russian Journal of General Chemistry. 90:1968-1973
ISSN: 1608-3350
1070-3632
Popis: For improving solubility of inosine, its β-form has been designed and prepared from inosine powder upon induction by sulfosalicylic acid. A single crystal of β-form inosine has been grown. The structure of β-form inosine has been characterized by XRPD, NMR and single-crystal X-ray crystallography. The crystal structure of β-form inosine demonstrates the layered structure based on a primary asymmetric cyclic hydrogen-bonded tetramer R44(14) based on the hetero-nitrogen and the hydroxyl group of inosine molecules. The single crystal exhibits the spiral structure along b axis formed due to O–H···O and O–H···N hydrogen bonds. As a result, water solubility under 37°C of inosine β-form is higher than that of inosine powder, and β-form inosine is hygroscopically more stable at 98% RH with respect to inosine powder. The β-form of inosine demonstrates the improved in vitro activity against liver cancer cells compared to inosine powder.
Databáze: OpenAIRE
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